The Abstract: Remembering Daniel Kahneman, Ph.D.

Plus, epigenetic aging, a new NAD+ precursor, and more.

Thanks for reading The Abstract. This months edition is

1,066 words, about a

4-minute read.

Is there a topic that youd like to see more of in

The Abstract? Drop us a line at

. Want to get

The Abstract in your inbox? Sign uphere.

ELYSIUM

The Abstract

April 2024

Welcome to the April edition of

The Abstract. This month, the most important science news in our world is remembering the incredible life of DanielDanny Kahneman, Ph.D., a visionary psychologist and beloved member of Elysiums Scientific Advisory Board. He passed away recently at the age of 90. With National DNA Day around the corner on April 25, we also cover a new study about epigenetic age as a predictor of life outcomes, the relationship between DNA repair and memory, and how leaky mitochondrial DNA drives cellular senescence. Finally, a novel NAD+ precursor called trigonelline is making headlines for its potential to combat agingmuscle.

Daniel Kahneman, Ph.D. (19342024)

Daniel Danny Kahneman, Ph.D., a visionary psychologist who won the 2002 Nobel Memorial Prize in Economic Sciences, has died at the age of 90. His research not only paved the way for the field of behavioral economics by integrating insights from psychological research into economic decision-making, it also had far-reaching effects on areas outside of academia, from sports to publichealth.

Kahneman was a beloved member of Elysium's Scientific Advisory Board, for which we feel incredibly fortunate. We particularly cherish his appreciation for his fellow thinkers:

Its entirely the people who I have met that excite me about Elysium Health, especially the Scientific Advisory Board, he said of his experience. It was an unbelievable honor to have him on our Board, and he will be greatlymissed.

All of us at Elysium are deeply saddened by Dannys passing, which is an immeasurable loss of a true scientific luminary, Elysium Health CEO Eric Marcotulli said.

Our grief, though profound, is tempered by the gratitude we hold for the intellectual legacy he leaves behindboth at Elysium and more broadly. We consider ourselves fortunate to have had the opportunity to know and work withDanny.

Read more

THIS MONTH

What Were Reading

These are third-party articles about science that we find interesting but have no relationship to Elysium or any of our products. Elysiums products are not intended to screen, diagnose, treat, cure, or prevent anydisease.

Epigenetic age measures predict life outcomes

A new study funded by the National Instituteon Aging supports the powerful contribution of biological age clocks to longevity science. Researchers analyzed data from more than 3,500 participants aged 51 and older to determine the association between epigenetic age acceleration and age-related health outcomes. They found that second and third generation epigenetic clocks (GrimAge, PhenoAge, DunedinPACE) consistently predicted health outcomes, including cognitive dysfunction, functional limitations, chronic conditions, and mortality. According to the NIA,

"The study findings suggest that along with traditional social and behavioral predictors of health, epigenetic age measures are a valuable tool for aging research and predicting health outcomes later in life. (National Institute onAging)

Basis and slower biological aging

PREDICTED RATE OF AGING | BASIS USE

Your daily Basis routine adds up. Based onepigenetic data, including from our

TIME-A longevity study, taking Basis consistently for two or more years was associated with a ~5% slower rate of aging.*These individuals also had slower rates of aging of the liver, kidneys, and inflammation and metabolicsystems.

Use the code

LONGEVITY at checkout for

25% off your first month ofBasis.

Learn about Basis

*Compared to individuals who did not take Basis. The data is based on 473 participants who self-reported their supplement use. Biological age can also be influenced by various environmental and lifestyle factors andchanges.

DNA repair is important for memory

Heres a surprising fact about making long-term memories: It requires DNA damage and brain inflammation. The finding comes from a new study in mice led by scientists at Albert Einstein College of Medicine and published in

Nature. Researchers trained mice to associate a small electrical shock with a new environmentto form a memory of itand tracked neuronal activity in the hippocampus, which plays a role in memory. They discovered that the memory-forming event causes double-strand DNA breaks, an inflammatory response, and the activation of DNA repair mechanisms. The study provides

the best evidence so far that DNA repair is important for memory, according to Toms Ryan, an engram neuroscientist at Trinity College Dublin. (Nature)

Leaky mitochondrial DNA drives cellular senescence

Cellular senescence is a fundamental mechanism or hallmark of aging. Senescent cells secrete pro-inflammatory molecules that can cause dysfunction and inflammation in neighboring cells and tissues. A new study led by researchers at Mayo Clinic implicates mitochondrial DNA (mtDNA) in this process. During apoptosis (programmed cell death), the outer membrane of mitochondria becomes porous and releases mtDNA into the cytosol. A healthy immune system typically clears these cells, but with age, more of these cells stickaround and become senescentsecreting damaging molecules in the process. Future therapies may target the release of mtDNA as a way of combating cellular senescence. (NIA)

Coffee molecule trigonelline is an NAD+ precursor

Trigonelline is a natural molecule found in coffee, fenugreek, and in the human bodyand its an NAD+ precursor with potential for treating sarcopenia, according to a new study. Researchers report in

Nature Metabolism that NAD+ levels, levels of trigonelline, and mitochondrial function are reduced in sarcopenia, the age-related loss of skeletal muscle and strength. In mouse models, they found that supplementing with trigonelline increased NAD+ levels, enhanced muscle strength, and prevented fatigue during aging. More research is needed to clarify the therapeutic benefit of trigonelline for muscle aging in humans. (NatureMetabolism)

TERM OF THE MONTH

Biological age

/ba.l.d.kl/ /ed/

Everyone ages at a different rate. Scientists estimate that genetics account for only 25% of this variation, with lifestyle and environmental factors providing the greater influence. Unlike chronological age, which tells you the number of years youve been alive, biological age measures the age your body is expected to perform or function, providing insights into your overall health. Biological age is calculated based on your epigeneticschemical modifications attached to your DNA that determine how your genes are expressedwhich are dynamic and modifiable. By monitoring your biological age over time, you can determine how diet and other lifestyle changes impact your rate ofaging.

AGING 101

New Aging 101: WhyNAD+ is everywhere right now

1945 | 1947 | 1949 | 2019 | 2021 | 2023

The recent buzz surrounding NAD+ is the result of decades of careful research. Since 1945, 70,557 scientific papers about NAD+ have been publishedand the number continues to grow. Learn how all of this research made it from the labs and scientific journals into social media and dinner table conversations. (Readmore)

insta

2024 Elysium Health Inc., 434 Broadway, Floor2, NewYork, NY10013

Call or text: (888) 220-6436

Unsubscribe

View in Your Browser

*LONGEVITY is valid only for monthly subscriptions of Basis. Valid on new purchases only and applies to first shipment only.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to screen, diagnose, treat, cure, or prevent any disease or condition or assess risk of any disease or condition. Unless advised by your healthcare professional, biological age should not be used to determine or alter any age-related health or medical treatments based on your chronologicalage.