Text Summary Of This Email
Methylation Risk Scores Explained
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This is my"Everything Epigenetics"newsletter, where I share the latest epigenetic optimization information, tools, and tips, on a monthly basis!
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EPIGENETICS UPDATE
Happy Holidays everyone! I hope you're able to spend time relaxing with loved ones.I wanted to spend some time talking about methylation risk scores (MRS). I truly believe this is the future of epigenetics - and healthcareYep, you heard it here first.
You may be familiar with polygenic risk scores (PRS), but have you ever heard of methylation risk scores?
MRS are crucial to understand, as theyre a tool that quantifies DNA methylation levels at specific genomic regions linked to particular conditions, shedding light on the potential impact of epigenetic modifications on disease susceptibility.
In contrast, PRS calculates an individuals genetic disease risk by considering multiple genetic variants across the genome, often identified through genome-wide association studies
While PRS offers valuable insights into genetic predisposition for complex diseases such as heart disease and diabetes, it has its limitations, including the risk of false positives and challenges in clinical interpretation.
The choice between MRS and PRS depends on the specific disease or research context and the available data, as both scores provide unique perspectives on disease risk.
Check out my podcast below with Dr. Mike Thompson to learn more.
EPIGENETICS PODCAST
From Polygenic Risk Score to Methylation Risk Scores
Episode 17: Methylation Risk Scoreswith Dr. Mike Thompson
Watch or Listen
Conquer Aging or Die Trying
Episode 18: Tracking and Measuring Biomarkers to Maximize Longevitywith Dr. Michael Lustgarten
EPIGENETICS EVENT
Wonderinghow to understand or make the most of your, or your patients',OMICm Age results? Check out a review of real, OMICm Age results, along with a breakdown of several other novel data offerings!
View the webinar by CLICKING HERE.You can view the PPT slides by CLICKING HERE.
Make sure to watch if you're interested in diving into the epigenetic findings from an OMICm Age case-study participant; highlighting key applications and takeaways from their OMICm AgeReport.
To make longevity and healthy aging a priority for modern healthcare, we must close the knowledge gap by extending education on the industry's latest developments to clinical practice.
Come visit me at LongevityFest 2023 in Las Vegas on Dec. 14th-16th. I will be representing my company, TruDiagnostic, at booth 7066.Register by CLICKING HERE.
EPIGENETICS IN THE LITERATURE
Clincal Applications of Methylation Risk Scores
Cancer is also a promising field where MRS may have potential for risk prediction. Epigenetics has an important role in cancer pathogenesis and subtype diagnosis. Some cancersubtypes have unique methylation profiles that could be used in classification. In 2020, astudyused MRS to predict the prognosis of colorectal cancer patients.
Combining MRS with other clinical information was found to have a better predictive value for tumor prognosis. Methylation has also been investigated for its potential to predict cancer grade forprostate cancerand to predictbladder cancer diagnosis.
Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age
A recent manuscript recently published in The Journals of Gerontologydelves into the dynamic link between epigenetic aging clocks and frailty in aging individuals. How do these biological age markers interact over time?
The study covers 524 individuals aged 50-90. They explored five different epigenetic clocks and their association with frailty using dual change score models. While frailty increases nonlinearly with age, epigenetic clocks typically rise linearly.
Some clocks showed associations primarily at age 50, while one, DunedinPACE, had a unique dynamic link with frailty. DunedinPACE stood out as a predictor of subsequent frailty, suggesting it could be an early marker of physiological decline.
These findings shed light on the temporal connection between epigenetic aging and frailty, emphasizing the value of understanding the pace of aging as a potential early indicator of physiological decline.
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-Hannah
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