How Epigenetics Solved the Natalia Grace Mystery🔎
Watch me on HBO, learn about my new series, and more!
Everything Epigenetics
Sent on 16 January 2024 07:30 AM
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Text Summary Of This Email
Watch me on HBO, learn about my new series, and more!
EPIGENETICS & LIFE UPDATE
Happy New Year everyone! I hope you've had a great first couple of weeks. I have some exciting news... I've recently been busy with an HBO documentary and some epigenetic sleuthing!Have you seen the documentary series The Curious Case of Natalia Grace?
If so, you may have noticed that an epigenetic test confirmed her true CHRONOLOGICAL age.
Using a first generation epigenetic clock, my company,TruDiagnostic, helped solve the infamous Natalia Grace mystery.
To learn more, check out my full interview with Lex18 HERE or by clicking the image below.
If you haven't seen the show,Natalia is a Ukrainian woman who was adopted by an Indiana couple as a girl.
Natalia has a form of dwarfism, and a decade ago, her original adoptive parents were accused of changing her legal age from eight to 22 because they believed she was actually an adult, and abandoning her to live alone in an apartment.
The adoptive father was acquitted of neglect charges and charges against the adoptive mother were dismissed.
TruDiagnostic stepped in to answer the question of whether Natalia Grace was a child or an adult when she was adopted back in 2010.
Our testing determined she is now about 22 years old chronoligcally, which means she would have been around eight years old when she was adopted.
MY NEW SERIES - Journal Club Friday
Every Friday, Im going to be diving into the latest and greatest research on Epigenetics.
Make sure to follow me on Instagram to stay up-to-date!
What questions do you have about about epigenetics? Are there any specific areas of research you want me to dive into?Reply to this email directly!
Click HERE or on the photos above for a full breakdown
EPIGENETICS PODCAST
How does the Great Depression Impact Aging?
Episode 21:Integrating Epigenetics into the Social Models of Health Disparitieswith Dr. Lauren Schmitz
Watch or Listen
The Seminal 2003 Agouti Mouse Study
Episode 22:The Importance of the Imprintomewith Dr. Randy Jirtle
EPIGENETICS IN THE LITERATURE
Biological Aging Acceleration Due to Environmental Exposures: An Exciting New Direction in Toxicogenomics Research
Biological clock technologies are designed to assess the acceleration of biological age (B-age) in diverse cell types, offering a distinctive opportunity in toxicogenomic research to explore the impact of environmental stressors, social challenges, and unhealthy lifestyles on health impairment.
These methods rely on assessing DNAm levels at specific CpG sites, RNA levels, and various biomolecules across multiple cell types, tissues, and entire organisms.
Commonly known as biological clocks (B-clocks), these estimators hold promise for gaining deeper insights into the pathways contributing to the development of age-related disorders.
They also provide a foundation for devising biomedical or social interventions to prevent, reverse, or mitigate these disorders.
This review article provides a concise overview of various epigenetic clocks and explores their susceptibility to environmental stressors.
Cancer epigenetics: from laboratory studies and clinical trials to precision medicine
Epigenetic dysregulation is a common feature of a myriad of human diseases, particularly cancer.
Defining the epigenetic defects associated with malignant tumors has become a focus of cancer research resulting in the gradual elucidation of cancer cell epigenetic regulation.
In fact, most stages of tumor progression, including tumorigenesis, promotion, progression, and recurrence are accompanied by epigenetic alterations, some of which can be reversed by epigenetic drugs.
The main objective of epigenetic therapy in the era of personalized precision medicine is to detect cancer biomarkers to improve risk assessment, diagnosis, and targeted treatment interventions.
Rapid technological advancements streamlining the characterization of molecular epigenetic changes associated with cancers have propelled epigenetic drug research and development.
This review summarizes the main mechanisms of epigenetic dysregulation and discusses past and present examples of epigenetic inhibitors in cancer diagnosis and treatment, with an emphasis on the development of epigenetic enzyme inhibitors or drugs.
In the final part, the prospect of precise diagnosis and treatment is considered based on a better understanding of epigenetic abnormalities in cancer.
STRUGGLING WITH YOUR EPIGENETICS?Reply to this email for support! I read every message.
-Hannah
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